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Functional analysis of two PLA2G2A variants associated with secretory phospholipase A2-IIA levels.

Exeter, HJ; Folkersen, L; Palmen, J; Franco-Cereceda, A; Cooper, JA; Kalea, AZ; Hooft, FV; ... Talmud, PJ; + view all (2012) Functional analysis of two PLA2G2A variants associated with secretory phospholipase A2-IIA levels. PLoS One , 7 (7) , Article e41139. 10.1371/journal.pone.0041139. Green open access

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Abstract

Secretory phospholipase A2 group IIA (sPLA2-IIA) has been identified as a biomarker of atherosclerosis in observational and animal studies. The protein is encoded by the PLA2G2A gene and the aim of this study was to test the functionality of two PLA2G2A non-coding SNPs, rs11573156 C>G and rs3767221 T>G where the rare alleles have been previously associated with higher and lower sPLA2-IIA levels respectively.

Type: Article
Title: Functional analysis of two PLA2G2A variants associated with secretory phospholipase A2-IIA levels.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0041139
Publisher version: http://dx.doi.org/10.1371/journal.pone.0041139
Language: English
Additional information: © 2012 Exeter et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC3412631 This work was supported by a British Heart Foundation PhD studentship FS08/048/25628 supporting HJE. The ASAP study was supported by the Swedish Research Council, the Swedish Heart-Lung foundation, and a donation by Fredrik Lundberg. SEH and PJT are supported by the British Heart Foundation RG008/014. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Keywords: Alleles, Alternative Splicing, Binding Sites, Electrophoretic Mobility Shift Assay, Genotype, Group II Phospholipases A2, Humans, Liver, MicroRNAs, Polymorphism, Single Nucleotide, Promoter Regions, Genetic, Protein Binding
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Centre for Cardiovascular Genetics
URI: https://discovery.ucl.ac.uk/id/eprint/1356636
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