Gosemann, JH;
Kuebler, JF;
Pozzobon, M;
Neunaber, C;
Hensel, JH;
Ghionzoli, M;
de Coppi, P;
... Holze, G; + view all
(2012)
Activation of regulatory T cells during inflammatory response is not an exclusive property of stem cells.
PLoS One
, 7
(4)
, Article e35512. 10.1371/journal.pone.0035512.
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Abstract
Sepsis and systemic-inflammatory-response-syndrome (SIRS) remain major causes for fatalities on intensive care units despite up-to-date therapy. It is well accepted that stem cells have immunomodulatory properties during inflammation and sepsis, including the activation of regulatory T cells and the attenuation of distant organ damage. Evidence from recent work suggests that these properties may not be exclusively attributed to stem cells. This study was designed to evaluate the immunomodulatory potency of cellular treatment during acute inflammation in a model of sublethal endotoxemia and to investigate the hypothesis that immunomodulations by cellular treatment during inflammatory response is not stem cell specific.
| Type: | Article |
|---|---|
| Title: | Activation of regulatory T cells during inflammatory response is not an exclusive property of stem cells. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0035512 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0035512 |
| Language: | English |
| Additional information: | PMCID: PMC3335124 © 2012 Gosemann et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. This study was financially supported by the “TUI Stiftung”, Hannover. PDC is supported by the Great Ormond Street Hospital Charity. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
| Keywords: | Amniotic Fluid, Animals, Cytokines, Endotoxemia, HEK293 Cells, Humans, Immunomodulation, Interleukin-2, Lipopolysaccharides, Lymphocyte Activation, Male, Mice, Mice, Inbred C3H, Neutrophils, Stem Cells, T-Lymphocytes, Regulatory |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1356423 |
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