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Modeling of ATP-mediated signal transduction and wave propagation in astrocytic cellular networks

Stamatakis, M; Mantzaris, NV; (2006) Modeling of ATP-mediated signal transduction and wave propagation in astrocytic cellular networks. Journal of Theoretical Biology , 241 (3) 649 - 668. 10.1016/j.jtbi.2006.01.002. Green open access

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Abstract

Astrocytes, a special type of glial cells, were considered to have supporting role in information processing in the brain. However, several recent studies have shown that they can be chemically stimulated by neurotransmitters and use a form of signaling, in which ATP acts as an extracellular messenger. Pathological conditions, such as spreading depression, have been linked to abnormal range of wave propagation in astrocytic cellular networks. Nevertheless, the underlying intra- and inter-cellular signaling mechanisms remain unclear. Motivated by the above, we constructed a model to understand the relationship between single-cell signal transduction mechanisms and wave propagation and blocking in astrocytic networks. The model incorporates ATP-mediated IP production, the subsequent Ca release from the ER through IPR channels and ATP release into the extracellular space. For the latter, two hypotheses were tested: Ca- or IP-dependent ATP release. In the first case, single astrocytes can exhibit excitable behavior and frequency-encoded oscillations. Homogeneous, one-dimensional astrocytic networks can propagate waves with infinite range, while in two dimensions, spiral waves can be generated. However, in the IP-dependent ATP release case, the specific coupling of the driver ATP-IP system with the driven Ca subsystem leads to one- and two-dimensional wave patterns with finite range of propagation. © 2006 Elsevier Ltd. All rights reserved.

Type: Article
Title: Modeling of ATP-mediated signal transduction and wave propagation in astrocytic cellular networks
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jtbi.2006.01.002
Publisher version: http://dx.doi.org/10.1016/j.jtbi.2006.01.002
Language: English
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Chemical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/1356196
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