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A common repressor pool results in indeterminacy of extrinsic noise

Stamatakis, M; Adams, RM; Balázsi, G; (2011) A common repressor pool results in indeterminacy of extrinsic noise. Chaos , 21 (4) 10.1063/1.3658618. Green open access

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Abstract

For just over a decade, stochastic gene expression has been the focus of many experimental and theoretical studies. It is now widely accepted that noise in gene expression can be decomposed into extrinsic and intrinsic components, which have orthogonal contributions to the total noise. Intrinsic noise stems from the random occurrence of biochemical reactions and is inherent to gene expression. Extrinsic noise originates from fluctuations in the concentrations of regulatory components or random transitions in the cell's state and is imposed to the gene of interest by the intra- and extra-cellular environment. The basic assumption has been that extrinsic noise acts as a pure input on the gene of interest, which exerts no feedback on the extrinsic noise source. Thus, multiple copies of a gene would be uniformly influenced by an extrinsic noise source. Here, we report that this assumption falls short when multiple genes share a common pool of a regulatory molecule. Due to the competitive utilization of the molecules existing in this pool, genes are no longer uniformly influenced by the extrinsic noise source. Rather, they exert negative regulation on each other and thus extrinsic noise cannot be determined by the currently established method. © 2011 American Institute of Physics.

Type: Article
Title: A common repressor pool results in indeterminacy of extrinsic noise
Open access status: An open access version is available from UCL Discovery
DOI: 10.1063/1.3658618
Language: English
Additional information: Copyright 2011 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. The following article appeared in Stamatakis, M; Adams, RM; Balázsi, G; (2011) A common repressor pool results in indeterminacy of extrinsic noise. Chaos , 21 (4) and may be found at http://dx.doi.org/10.1063/1.3658618
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Chemical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/1356191
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