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Is transcranial sonography useful to distinguish scans without evidence of dopaminergic deficit patients from Parkinson's disease?

Stockner, H; Schwingenschuh, P; Djamshidian, A; Silveira-Moriyama, L; Katschnig, P; Seppi, K; Dickson, J; ... Bhatia, KP; + view all (2012) Is transcranial sonography useful to distinguish scans without evidence of dopaminergic deficit patients from Parkinson's disease? Movement Disorders , 27 (9) 1182 - 1185. 10.1002/mds.25102. Green open access

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Abstract

Approximately 10% of patients clinically diagnosed with early Parkinson's disease (PD) subsequently have normal dopaminergic functional imaging. Transcranial sonography (TCS) has been shown to detect midbrain hyperechogenicity in approximately 90% of Parkinson's disease (PD) patients and 10% of the healthy population. The aim of this study was to investigate the prevalence of midbrain hyperechogenicity in patients with suspected parkinsonism and scans without evidence of dopaminergic deficit (SWEDD), in comparison to PD patients.

Type: Article
Title: Is transcranial sonography useful to distinguish scans without evidence of dopaminergic deficit patients from Parkinson's disease?
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/mds.25102
Publisher version: http://dx.doi.org/10.1002/mds.25102
Language: English
Additional information: This work is licensed under the Creative Commons Attribution License, Attribution 3.0 Unported (CC BY 3.0) http://creativecommons.org/licenses/by/3.0/ which permits unrestricted use, distribution, and reproduction in any medium. However, you must attribute the work to the author (but not in any way that suggests that they endorse you or your use of the work). PMCID: PMC3660780
Keywords: Aged, Cognition Disorders, Diagnosis, Differential, Dopamine, Female, Humans, Magnetic Resonance Imaging, Male, Mesencephalon, Middle Aged, Nerve Fibers, Myelinated, Neuropsychological Tests, Parkinson Disease, Positron-Emission Tomography, Temporal Bone, Ultrasonography, Doppler, Transcranial
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/1354526
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