Cheema, U; Yang, S; Mudera, V; Goldspink, G; Brown, RA; (2002) Mechanical loading of 3-D muscle constructs. In: Abstracts of TCES 2002 Annual meeting of the UK Tissue and Cell Engineering Society 19-20 September 2002, The University of Glasgow, Scotland. (pp. 16 - 17).

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Abstract

Mechanical conditioning of many tissue engineered construct will be critical, particularly mechano-responsive tissues such as skeletal muscle. It has been shown that application of defined uniaxial loads to 3D constructs through the tensioning- culture force monitor (t-CFM), has been shown to regulate protease expression in fibroblasts (Prajapati et al. 2000). Insulin-like growth factor (IGF-1) is an important growth factor in proliferation and differentiation of skeletal myoblasts (Florini et al. 1996), along with it a recently isolated isoform, mechano-growth factor (MGF) is found to be upregulated in skeletal muscle in vivo following exercise (Yang et al. 1996).

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