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Interplay between path and speed in decision making by high-dimensional stochastic gene regulatory networks.

Nené, NR; Zaikin, A; (2012) Interplay between path and speed in decision making by high-dimensional stochastic gene regulatory networks. PLoS One , 7 (7) , Article e40085. 10.1371/journal.pone.0040085. Green open access

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Abstract

Induction of a specific transcriptional program by external signaling inputs is a crucial aspect of intracellular network functioning. The theoretical concept of coexisting attractors representing particular genetic programs is reasonably adapted to experimental observations of "genome-wide" expression profiles or phenotypes. Attractors can be associated either with developmental outcomes such as differentiation into specific types of cells, or maintenance of cell functioning such as proliferation or apoptosis. Here we review a mechanism known as speed-dependent cellular decision making (SdCDM) in a small epigenetic switch and generalize the concept to high-dimensional space. We demonstrate that high-dimensional network clustering capacity is dependent on the level of intrinsic noise and the speed at which external signals operate on the transcriptional landscape.

Type: Article
Title: Interplay between path and speed in decision making by high-dimensional stochastic gene regulatory networks.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0040085
Publisher version: http://dx.doi.org/10.1371/journal.pone.0040085
Language: English
Additional information: © 2012 Nené, Zaikin. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC3398018 NRN acknowledges financial support from the Engineering and Physical Sciences Research Council at CoMPLEX, University College London. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Womens Cancer
URI: https://discovery.ucl.ac.uk/id/eprint/1353709
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