Nené, NR;
Zaikin, A;
(2012)
Interplay between path and speed in decision making by high-dimensional stochastic gene regulatory networks.
PLoS One
, 7
(7)
, Article e40085. 10.1371/journal.pone.0040085.
![[thumbnail of 1353709.pdf]](https://discovery.ucl.ac.uk/style/images/fileicons/application_pdf.png) Preview |
PDF
1353709.pdf Download (1MB) |
Abstract
Induction of a specific transcriptional program by external signaling inputs is a crucial aspect of intracellular network functioning. The theoretical concept of coexisting attractors representing particular genetic programs is reasonably adapted to experimental observations of "genome-wide" expression profiles or phenotypes. Attractors can be associated either with developmental outcomes such as differentiation into specific types of cells, or maintenance of cell functioning such as proliferation or apoptosis. Here we review a mechanism known as speed-dependent cellular decision making (SdCDM) in a small epigenetic switch and generalize the concept to high-dimensional space. We demonstrate that high-dimensional network clustering capacity is dependent on the level of intrinsic noise and the speed at which external signals operate on the transcriptional landscape.
| Type: | Article |
|---|---|
| Title: | Interplay between path and speed in decision making by high-dimensional stochastic gene regulatory networks. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0040085 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0040085 |
| Language: | English |
| Additional information: | © 2012 Nené, Zaikin. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC3398018 NRN acknowledges financial support from the Engineering and Physical Sciences Research Council at CoMPLEX, University College London. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Womens Cancer |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1353709 |
Archive Staff Only
 |
View Item |
