Raison, C; Porter, SR; Fedele, S; Lewis, MP; Salih, V; (2011) In vitro 3D tissue modelling: Insights into ameloblastoma pathogenesis. In: Abstracts of the Tissue and Cell Engineering Society (TCES) meeting 19-21 July 2011, University of Leeds. (pp. 54 - 54).

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Abstract

Ameloblastoma is a rare, benign oral tumour. Tumours develop within the jaw bone and are highly destructive and invasive, with cells migrating into the jaw and surrounding soft tissue. This is a little-understood disease which if left untreated causes dramatic bone destruction and maxillofacial disfigurement. Current treatment is radical surgery, often resulting in extensive loss of function and tissue. An ameloblastoma-derived cell line, AM-1, has been established [1]. Cells were isolated from a human tumour and immortalised by the addition of HPV-16 DNA. This study aims to (i) make a 3D in vitro ameloblastoma disease model, using plastic-compressed collagen gel [2] seeded with AM-1 cells, and (ii) use this bone construct to characterise tissue remodelling, cell growth and invasiveness.

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