Bohr, A; Memarzadeh, K; Alp, B; Brown, R; Salih, V; (2009) Single unconfined compression of cellular dense collagen scaffolds for cartilage and bone tissue engineering. In: Abstracts of the Tissue and Cell Engineering Society (TCES) meeting 8-10 July 2009, Universities of Glasgow & Strathclyde. (pp. 47 - 47).

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Abstract

Cell seeded collagen matrix scaffolds have been extensively evaluated recently as potential systems for de-novo tissue regeneration and repair for a variety of tissue types. While collagen gels are biologically excellent as starting point scaffold materials, their use is limited by the lack of cohesive structure and inherently weak mechanical properties due to a high liquid content (>99%). An ingenious method of combining unconfined plastic compression (PC) with capillary action has shown that these scaffolds can be rapidly processed into tissue like structures, which can be immediately implanted into the host[1]. It has been shown that the rapid increase in fibrillar collagen density dramatically enhanced the mechanical properties of such scaffolds thus potentially eliminating the need for long term cellular action. This simple project investigated the effect of single unconfined compression on cartilage-cell seeded collagen matrices in terms of cell viability, proliferation and oxygen consumption.

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