Bitar, M;
Knowles, JC;
Salih, V;
Lewis, MP;
(2004)
Biocompatible phosphate glass fibre scaffolds engineering of the hard/ soft tissue interface.
In:
Abstracts of eCells and Materials V The Cell Biomaterial Reaction 28th - 30th June 2004, Congress Centre, Davos, Switzerland.
(pp. 26 - 26).
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Abstract
Phosphate based glasses maintain the survival, phenotype and morphology of adherent human bone and ligament cells (1) and may prove ideal, as scaffolding material, for tissue engineering dealing with ligament-tendon/ bone attachment defects. This work assesses the biocompatibility of fibre constructs of both, ternary (CaO–Na2O–P2O5) and Quaternary (iron containing) compositions as candidates for a contiguous osteoblast/ fibroblast seeded in vitro systems. This is achieved by firstly, identifying the optimum fibre diameter and secondly, comparing various glass compositions for biocompatibility through evaluating cell adhesion, proliferation and morphology.
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