UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Introducing stable microgrooves in to fluid-leaving surface of plastic compressed collagen by embossing

Alekseeva, T; Tully, F; Knowles, JC; Brown, RA; (2011) Introducing stable microgrooves in to fluid-leaving surface of plastic compressed collagen by embossing. In: Abstracts of the Tissue and Cell Engineering Society (TCES) meeting 28-30 July 2010, University of Manchester. (pp. 30 - 30). Green open access

[thumbnail of Vol22supp02a30.pdf] PDF
Vol22supp02a30.pdf
Available under License : See the attached licence file.

Download (51kB)

Abstract

Micropatterning of polymers is a technique used in tissue engineering to create additional features on the surface usually to manipulate cell behaviour. However, methods used for fabrication of such features on the surface of synthetic polymers are not always suitable for natural polymers. Here we describe a method of embossing developed for plastic compressed collagen constructs. Plastic compression (PC) of collagen is a technique that allows cell-independent fabrication of dense, tissue-like collagen constructs without compromising viability of resident cells (1). Method of PC creates potential anisotropy of the opposite surfaces – stiffer fluid leaving (closest to the blotting elements) and more elastic non-fluid leaving surface. We hypothesized that embossing into these surfaces will give more stable features on the fluid-leaving surface (FLS) as opposed to non fluid-leaving surface (NFLS). Objectives were to develop methods of embossing onto both surfaces, assess these features and to determine stability of the embossed pattern over time with and without cells. Slow-dissolving phosphate-based glass fibers were used as the embossing template in this study as fiber diameter and spacing is easily controlled.

Type: Proceedings paper
Title: Introducing stable microgrooves in to fluid-leaving surface of plastic compressed collagen by embossing
Event: Tissue and Cell Engineering Society (TCES) meeting
Location: University of Manchester
Dates: 28 July 2010-30 July 2010
Open access status: An open access version is available from UCL Discovery
Publisher version: http://www.ecmjournal.org/journal/supplements/vol0...
Language: English
Additional information: Reproduced with kind permission from eCM journal (www.ecmjournal.org)
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Biomaterials and Tissue Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1352722
Downloads since deposit
63Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item