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If the treatment works, do we need to know why?: the promise of immunotherapy for experimental medicine

Ehrenstein, MR; Mauri, C; (2007) If the treatment works, do we need to know why?: the promise of immunotherapy for experimental medicine. The Journal of Experimental Medicine , 204 (10) 2249 - 2252. 10.1084/jem.20071737. Green open access

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Abstract

There has been much fanfare, and rightly so, heralding a revolution in the treatment of autoimmune disease using biologic agents - antibodies or other molecules that specifically target known mediators of disease. But not all patients respond to even the most successful biologic agent, which may provide clues about alternate disease mechanisms. Studies aimed at understanding the mechanism of action of biologic agents will yield significant benefits for experimental medicine.

Type: Article
Title: If the treatment works, do we need to know why?: the promise of immunotherapy for experimental medicine
Open access status: An open access version is available from UCL Discovery
DOI: 10.1084/jem.20071737
Publisher version: http://dx.doi.org/10.1084/jem.20071737
Language: English
Additional information: Publication available under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license described at http://creativecommons.org/licenses/by-nc-sa/3.0/ and http://creativecommons.org/licenses/by-nc-sa/3.0/legalcode. This provides the non-exclusive right to copy, distribute, or display the Work is granted after six months of publication.
Keywords: Tumor-necrosis-factor, collagen-induced arthritis, experimental allergic encephalomyelitis, x-linked agammaglobulinemia, cell-deficient mice, crohns-disease, rheumatoid-arthritis, b-cells, factor-alpha, tnf-alpha
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/135243
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