Todd, AK;
Neidle, S;
(2008)
The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements.
Nucleic Acids Res
, 36
(8)
2700 - 2704.
10.1093/nar/gkn078.
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Abstract
We have carried out a survey of potential quadruplex structure sequences (PQSS), which occur in the immediate upstream region (500 bp) of human genes. By examining the number and distribution of these we have established that there is a clear link between them and the occurrence of the SP1-binding element 'GGGCGG', such that a large number of upstream PQSS incorporate the SP1-binding element.
| Type: | Article |
|---|---|
| Title: | The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements. |
| Location: | England |
| Identifier: | PMCID: PMC2377421 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/nar/gkn078 |
| Publisher version: | http://dx.doi.org/10.1093/nar/gkn078 |
| Language: | English |
| Additional information: | © 2008 The Author(s) This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Base Sequence, Consensus Sequence, G-Quadruplexes, Genome, Human, Genomics, Humans, Promoter Regions, Genetic, Regulatory Elements, Transcriptional, Sp1 Transcription Factor |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1351733 |
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