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The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements.

Todd, AK; Neidle, S; (2008) The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements. Nucleic Acids Res , 36 (8) 2700 - 2704. 10.1093/nar/gkn078. Green open access

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Abstract

We have carried out a survey of potential quadruplex structure sequences (PQSS), which occur in the immediate upstream region (500 bp) of human genes. By examining the number and distribution of these we have established that there is a clear link between them and the occurrence of the SP1-binding element 'GGGCGG', such that a large number of upstream PQSS incorporate the SP1-binding element.

Type: Article
Title: The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements.
Location: England
Identifier: PMCID: PMC2377421
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/nar/gkn078
Publisher version: http://dx.doi.org/10.1093/nar/gkn078
Language: English
Additional information: © 2008 The Author(s) This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Base Sequence, Consensus Sequence, G-Quadruplexes, Genome, Human, Genomics, Humans, Promoter Regions, Genetic, Regulatory Elements, Transcriptional, Sp1 Transcription Factor
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
URI: https://discovery.ucl.ac.uk/id/eprint/1351733
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