Todd, AK;
Johnston, M;
Neidle, S;
(2005)
Highly prevalent putative quadruplex sequence motifs in human DNA.
Nucleic Acids Res
, 33
(9)
2901 - 2907.
10.1093/nar/gki553.
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Abstract
We report here the results of a systematic search for the existence and prevalence of potential intramolecular G-quadruplex forming sequences in the human genome. We have also examined the tendency for particular sequences of 'loop' regions to occur in particular positions with respect to the G-tracts in a quadruplex. Using arithmetic ratio and probability techniques we have discovered frequent and systematic occurrence of certain sequence types, the most prominent being a potential quadruplex containing CCTGT in the first 'loop' position. Being able to highlight types of potential quadruplex sequences in G-rich regions is an important step in searching for biologically relevant sequences and finding their function.
| Type: | Article |
|---|---|
| Title: | Highly prevalent putative quadruplex sequence motifs in human DNA. |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/nar/gki553 |
| Publisher version: | http://dx.doi.org/10.1093/nar/gki553 |
| Language: | English |
| Additional information: | PMCID: PMC1140077. © The Author 2005. Published by Oxford University Press. All rights reserved The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oupjournals.org |
| Keywords: | Base Sequence, Computational Biology, DNA, G-Quadruplexes, Genome, Human, Guanine, Humans, Molecular Sequence Data, Nucleic Acid Conformation, Sequence Analysis, DNA |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1351706 |
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