Shepherd, A; Brown, R; Bozec, L; (2009) Micro thermal analysis: A novel method of determining the extent of collagen cross-linking within a collagen construct- applications for tissue engineering. In: Abstracts of the Tissue and Cell Engineering Society (TCES) meeting 8-10 July 2009, Universities of Glasgow & Strathclyde. (pp. 99 - 99).

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Abstract

Increasingly complex designs of collagen scaffolds used in tissue engineering require more accurate and sensitive methods of testing. A new proposal to create cross-linked tunnels within a collagen scaffold for use in vascular and nerve studies will require a novel method of assessing the extent of cross-linking within the walls of the tube- to ensure maximal strength for matrix viability. To date this method has not yet been investigated. Aim: this study will investigate ways to differentiate between cross-linked and native collagen using melting characteristics found by Micro thermal analysis at point regions throughout the construct to give a detailed intra-matrix map.

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