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Evaluation of genetic markers as instruments for Mendelian randomization studies on vitamin D.

Berry, DJ; Vimaleswaran, KS; Whittaker, JC; Hingorani, AD; Hyppönen, E; (2012) Evaluation of genetic markers as instruments for Mendelian randomization studies on vitamin D. PLoS One , 7 (5) , Article e37465. 10.1371/journal.pone.0037465. Green open access

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Abstract

Mendelian randomization (MR) studies use genetic variants mimicking the influence of a modifiable exposure to assess and quantify a causal association with an outcome, with an aim to avoid problems with confounding and reverse causality affecting other types of observational studies.

Type: Article
Title: Evaluation of genetic markers as instruments for Mendelian randomization studies on vitamin D.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0037465
Publisher version: http://dx.doi.org/10.1371/journal.pone.0037465
Language: English
Additional information: © 2012 Berry et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC3357436 This study was supported by grants from the British Heart Foundation and the UK Medical Research Council [project grant G0601653, PrevMetSyn/SALVE with Academy of Finland]. EH is a Department of Health (UK) Public Health Career Scientist. The 25-hydroxyvitamin D assay in the 1958 British birth cohort was funded by the BUPA foundation. Genotype data from the 1958 British birth cohort DNA collection was funded by MRC grant G0000934 and Wellcome Trust grant 068545/Z/02. This research used resources provided by the Type 1 Diabetes Genetics Consortium, a collaborative clinical study sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute of Allergy and Infectious Diseases, National Human Genome Research Institute, National Institute of Child Health and Human Development, and Juvenile Diabetes Research Foundation International (JDRF) and supported by U01 DK062418. This study also makes use of data generated by the Wellcome Trust Case-Control Consortium. A full list of the investigators who contributed to the generation of the data is available from www.wtccc.org.uk. Funding for the project was provided by the Wellcome Trust under award 076113. The work was undertaken at the Centre for Paediatric Epidemiology and Biostatistics which benefits from funding support from the MRC in its capacity as the MRC Centre of Epidemiology for Child Health. Research at the University College London Institute of Child Health and Great Ormond Street Hospital for Children NHS Trust benefits from R&D funding received from the NHS Executive. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Keywords: Adult, Alleles, European Continental Ancestry Group, Female, Genetic Markers, Genetic Predisposition to Disease, Genotype, Humans, Male, Mendelian Randomization Analysis, Middle Aged, Polymorphism, Single Nucleotide, Vitamin D
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Developmental Neurosciences Prog
URI: https://discovery.ucl.ac.uk/id/eprint/1348827
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