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Endothelial cell migration and aggregation in response to hypoxia-induced signalling

Cheema, U; Hadjipanayi, E; Mudera, V; Deng, D; Liu, W; Brown, RA; (2011) Endothelial cell migration and aggregation in response to hypoxia-induced signalling. In: Abstracts of the Tissue and Cell Engineering Society (TCES) meeting 28-30 July 2010, University of Manchester. (pp. 5 - 5). Green open access

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Abstract

The vascularisation of any graft, engineered implant or injury site is a key factor for optimal repair and regeneration. New blood vessel formation is a physiological response to tissue hypoxia, through upregulation of angiogenic factor signalling. We engineered cell-mediated hypoxia in a convenient cell type, human dermal fibroblasts (HDFs), to form a population of Hypoxia-Induced Signalling (HIS) cells and showed that HIS responses by HDFs induce endothelial cell (EC) migration and tubule formation both in vitro and in vivo

Type: Proceedings paper
Title: Endothelial cell migration and aggregation in response to hypoxia-induced signalling
Event: Tissue and Cell Engineering Society (TCES) meeting
Location: University of Manchester
Dates: 28 July 2010-30 July 2010
Open access status: An open access version is available from UCL Discovery
Publisher version: http://www.ecmjournal.org/journal/supplements/vol0...
Language: English
Additional information: Reproduced with kind permission from eCM journal (www.ecmjournal.org)
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science
URI: https://discovery.ucl.ac.uk/id/eprint/1348472
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