UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Cytokines modulated myofibroblast induction and force generation in dupuytren's fibroblasts; Lessons for tissue engineering?

Verhoekx, JSN; van der Werff, JFA; Mudera, V; (2011) Cytokines modulated myofibroblast induction and force generation in dupuytren's fibroblasts; Lessons for tissue engineering? In: Abstracts of the Tissue and Cell Engineering Society (TCES) meeting 19-21 July 2011, University of Leeds. (pp. 45 - 45). Green open access

[thumbnail of Vol22supp03a45.pdf] PDF
Vol22supp03a45.pdf
Available under License : See the attached licence file.

Download (213kB)

Abstract

Tissue engineering aims to get cells in vitro to lay down collagen and generate living functional 3D structures for implantation. The major challenge is getting fibroblasts to lay down functional collagen in vitro. We studied a natural condition where fibroblasts secrete excess collagen and shorten the matrix by remodelling it (Dupuytren’s disease). Some of the collagen layed down is organised and has the structure of tendon (cord) but the active state is the nodule. The cells responsible for the fibrotic contractures seen in Dupuytren’s disease are the myofibroblasts, expressing α-smooth muscle actin (α-SMA), correlating with increased deposition of extracellular matrix (ECM) components1 and contractile force generation, contracting the ECM2. Cytokines are potential targets for myofibroblast modulation, as they control expression of myofibroblast marker α-SMA3. We have examined the effect of cytokines, TGF-β1 and PDGF-BB, on force generation and matrix remodeling.

Type: Proceedings paper
Title: Cytokines modulated myofibroblast induction and force generation in dupuytren's fibroblasts; Lessons for tissue engineering?
Event: Tissue and Cell Engineering Society (TCES) meeting
Location: University of Leeds
Dates: 19/07/2011-21/07/2011
Open access status: An open access version is available from UCL Discovery
Publisher version: http://www.ecmjournal.org/journal/supplements/vol0...
Language: English
Additional information: Reproduced with kind permission from eCM journal (www.ecmjournal.org)
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
URI: https://discovery.ucl.ac.uk/id/eprint/1348471
Downloads since deposit
89Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item