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Engineering angiogenesis by hypoxia-induced signaling: Adopting a physiological approach

Hadjipanayi, E; Brown, RA; Mudera, V; Cheema, U; (2009) Engineering angiogenesis by hypoxia-induced signaling: Adopting a physiological approach. In: Abstracts of the Tissue and Cell Engineering Society (TCES) meeting 8-10 July 2009, Universities of Glasgow & Strathclyde. (pp. 15 - 15). Green open access

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Abstract

Successful engineering of tissues with clinically relevant size and complexity critically depends on their in vitro pre-vascularization which can promote cell survival, differentiation and rapid vascularization post-implantation. However, mimicking in vitro the physiological complexity of a vascular network currently presents major obstacles1. In this study we tested the hypothesis that a hypoxia-induced signaling (HIS) - cell population can generate the complete angiogenic cascade necessary for inducing endothelial cell sprouting and tubule formation within a 3D construct.

Type: Proceedings paper
Title: Engineering angiogenesis by hypoxia-induced signaling: Adopting a physiological approach
Event: Tissue and Cell Engineering Society (TCES) meeting
Location: Universities of Glasgow & Strathclyde
Dates: 08 Jul 2009 - 10 Jul 2009
Open access status: An open access version is available from UCL Discovery
Publisher version: http://www.ecmjournal.org/journal/supplements/vol0...
Language: English
Additional information: Reproduced with kind permission from eCM journal (www.ecmjournal.org)
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science
URI: https://discovery.ucl.ac.uk/id/eprint/1348469
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