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Spatial layering of cells in a novel poly(lactic acid-co-caprolactone)-collagen hybrid construct

Ananta, M; Hilborn, J; Aulin, C; Houis, S; Brown, R; Mudera, V; (2008) Spatial layering of cells in a novel poly(lactic acid-co-caprolactone)-collagen hybrid construct. In: Abstracts of the Tissue and Cell Engineering Society (TCES) meeting 2-4 July 2008, University of Nottingham. (pp. 34 - 34). Green open access

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Abstract

INTRODUCTION: Advantages of synthetic polymers as a scaffolding material include the ability to produce them on a large scale and the ability to tailor their physical and mechanical properties to exact specification. A continuing difficulty is the uncertainty of cell seeding, largely due to a non-ideal surface chemistry. Natural biopolymers on the other hand, provide a substrate for cell-adhesion, are highly organized, and have the ability to induce tissue growth. A main disadvantage, however, is that they are less readily available and their mechanical and physical properties are difficult to control. The concept of combining these two biomaterials and their advantages is attractive. In this study we have fabricated a hybrid construct consisting of a synthetic polymer mesh coated with hyperhydrated collagen gels, which were plastic compressed.

Type: Proceedings paper
Title: Spatial layering of cells in a novel poly(lactic acid-co-caprolactone)-collagen hybrid construct
Event: Tissue and Cell Engineering Society (TCES) meeting
Location: University of Nottingham
Dates: 02 July 2008- 04 July 2008
Open access status: An open access version is available from UCL Discovery
Publisher version: http://www.ecmjournal.org/journal/supplements/vol0...
Language: English
Additional information: Reproduced with kind permission from eCM journal (www.ecmjournal.org)
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
URI: https://discovery.ucl.ac.uk/id/eprint/1348464
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