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Properties of end-stage human T cells defined by CD45RA re-expression.

Henson, SM; Riddell, NE; Akbar, AN; (2012) Properties of end-stage human T cells defined by CD45RA re-expression. Current Opinion in Immunology , 24 (4) 476 - 481. 10.1016/j.coi.2012.04.001. Green open access

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Abstract

Persistent viral infections, inflammatory syndromes and ageing all induce the accumulation of highly differentiated CD45RA re-expressing memory T cells. These cells increase during ageing, especially in individuals who are infected with cytomegalovirus (CMV). These cells have decreased proliferative capacity, increased activation of senescence signalling pathways and greater susceptibility to apoptosis in vitro. However these cells are capable of multiple effector functions and thus bear all the hallmarks of short-lived effector T cells. This indicates that senescence signalling may govern the unique characteristics of effector T cells. In this article, we address the functional and migratory properties of these T cells and mechanisms that are involved in their generation. Finally we assess the potential for manipulation of their activity and whether this may improve immune function during ageing.

Type: Article
Title: Properties of end-stage human T cells defined by CD45RA re-expression.
Location: UK
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.coi.2012.04.001
Publisher version: http://dx.doi.org/10.1016/j.coi.2012.04.001
Language: English
Additional information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Antigens, CD45, Cell Aging, Humans, T-Lymphocytes
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/1347224
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