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Nitric Oxide Manipulation: A Therapeutic Target for Peripheral Arterial Disease?

Williams, G; Shi-Wen, X; Abraham, D; Selvakumar, S; Baker, DM; Tsui, JC; (2012) Nitric Oxide Manipulation: A Therapeutic Target for Peripheral Arterial Disease? Cardiology Research and Practice , 2012 , Article 656247. 10.1155/2012/656247. Green open access

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Abstract

Peripheral Arterial Disease (PAD) is a cause of significant morbidity and mortality in the Western world. Risk factor modification and endovascular and surgical revascularisation are the main treatment options at present. However, a significant number of patients still require major amputation. There is evidence that nitric oxide (NO) and its endogenous inhibitor asymmetric dimethylarginine (ADMA) play significant roles in the pathophysiology of PAD. This paper reviews experimental work implicating the ADMA-DDAH-NO pathway in PAD, focussing on both the vascular dysfunction and effects within the ischaemic muscle, and examines the potential of manipulating this pathway as a novel adjunct therapy in PAD.

Type: Article
Title: Nitric Oxide Manipulation: A Therapeutic Target for Peripheral Arterial Disease?
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1155/2012/656247
Publisher version: http://dx.doi.org/10.1155/2012/656247
Language: English
Additional information: Copyright © 2012 Gareth Williams et al. This is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/1346591
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