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Modifying three-dimensional scaffolds from novel nanocomposite materials using dissolvable porogen particles for use in liver tissue engineering.

Adwan, H; Fuller, B; Seldon, C; Davidson, B; Seifalian, A; (2013) Modifying three-dimensional scaffolds from novel nanocomposite materials using dissolvable porogen particles for use in liver tissue engineering. J Biomater Appl , 28 (2) 250 - 261. 10.1177/0885328212445404. Green open access

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Abstract

Although hepatocytes have a remarkable regenerative power, the rapidity of acute liver failure makes liver transplantation the only definitive treatment. Attempts to incorporate engineered three-dimensional liver tissue in bioartificial liver devices or in implantable tissue constructs, to treat or bridge patients to self-recovery, were met with many challenges, amongst which is to find suitable polymeric matrices. We studied the feasibility of utilising nanocomposite polymers in three-dimensional scaffolds for hepatocytes.

Type: Article
Title: Modifying three-dimensional scaffolds from novel nanocomposite materials using dissolvable porogen particles for use in liver tissue engineering.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/0885328212445404
Publisher version: http://dx.doi.org/10.1177/0885328212445404
Language: English
Additional information: © The Author(s) 2012. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(http://www.uk.sagepub.com/aboutus/openaccess.htm). PMCID: PMC4107826
Keywords: HepG2, POSS-modified polycaprolactone urea urethane, hepatocytes, nanocomposite polymers, porogens, scaffolds, tissue engineering, Cell Adhesion, Glucose, Hep G2 Cells, Humans, Liver, Nanocomposites, Organosilicon Compounds, Polyesters, Polyurethanes, Porosity, Sodium Bicarbonate, Sodium Chloride, Tissue Engineering, Tissue Scaffolds
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/1346578
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