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A randomised trial of granulocyte-macrophage colony-stimulating factor for neonatal sepsis: outcomes at 2 years

Marlow, N; Morris, T; Brocklehurst, P; Carr, R; Cowan, FM; Patel, N; Petrou, S; ... Dore, C; + view all (2013) A randomised trial of granulocyte-macrophage colony-stimulating factor for neonatal sepsis: outcomes at 2 years. Archives of Disease in Childhood Fetal and Neonatal Edition , 98 (1) F46 - F53. 10.1136/fetalneonatal-2011-301470. Green open access

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Abstract

The authors performed a randomised trial in very preterm small-for-gestational age (SGA) babies to determine if prophylaxis with granulocyte-macrophage colony-stimulating factor (GM-CSF) improves outcomes (the PROGRAMS trial). Despite increased neutrophil counts following GM-CSF, the authors reported no significant difference in neonatal sepsis-free survival.

Type: Article
Title: A randomised trial of granulocyte-macrophage colony-stimulating factor for neonatal sepsis: outcomes at 2 years
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/fetalneonatal-2011-301470
Publisher version: http://dx.doi.org/10.1136/fetalneonatal-2011-30147...
Language: English
Additional information: © 2012 The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License (CC BY-NC), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/3.0/ and http://creativecommons.org/licenses/by-nc/3.0/legalcode PMCID: PMC3533400
Keywords: Developmental Disabilities, Disabled Children, Disease-Free Survival, Female, Granulocyte-Macrophage Colony-Stimulating Factor, Humans, Infant, Extremely Premature, Infant, Newborn, Infant, Premature, Diseases, Infant, Small for Gestational Age, Male, Sepsis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > Comprehensive CTU at UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Applied Health Research
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Neonatology
URI: https://discovery.ucl.ac.uk/id/eprint/1346532
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