Djamshidian, A;
O'Sullivan, SS;
Lees, A;
Averbeck, BB;
(2012)
Effects of dopamine on sensitivity to social bias in Parkinson's disease.
PLoS One
, 7
(3)
, Article e32889. 10.1371/journal.pone.0032889.
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Abstract
Patients with Parkinson's disease (PD) sometimes develop impulsive compulsive behaviours (ICBs) due to their dopaminergic medication. We compared 26 impulsive and 27 non-impulsive patients with PD, both on and off medication, on a task that examined emotion bias in decision making. No group differences were detected, but patients on medication were less biased by emotions than patients off medication and the strongest effects were seen in patients with ICBs. PD patients with ICBs on medication also showed more learning from negative feedback and less from positive feedback, whereas off medication they showed the opposite effect.
| Type: | Article |
|---|---|
| Title: | Effects of dopamine on sensitivity to social bias in Parkinson's disease. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0032889 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0032889 |
| Language: | English |
| Additional information: | This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. PMCID: PMC3298454 This study was funded by the Reta Lila Howard Foundation, the Intramural research program of the NIH and the Wellcome Trust. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
| Keywords: | Aged, Analysis of Variance, Compulsive Behavior, Decision Making, Dopamine, Emotions, Face, Female, Humans, London, Male, Middle Aged, Parkinson Disease, Photic Stimulation, Recognition (Psychology) |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1346213 |
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