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Theoretical and experimental characterisation of magnetic microbubbles.

Mulvana, H; Eckersley, RJ; Tang, MX; Pankhurst, Q; Stride, E; (2012) Theoretical and experimental characterisation of magnetic microbubbles. Ultrasound in Medicine & Biology , 38 (5) 864 - 875. 10.1016/j.ultrasmedbio.2012.01.027. Green open access

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Abstract

In addition to improving image contrast, microbubbles have shown great potential in molecular imaging and drug/gene delivery. Previous work by the authors showed that considerable improvements in gene transfection efficiency were obtained using microbubbles loaded with magnetic nanoparticles under simultaneous exposure to ultrasound and magnetic fields. The aim of this study was to characterise the effect of nanoparticles on the dynamic and acoustic response of the microbubbles. High-speed video microscopy indicated that the amplitude of oscillation was very similar for magnetic and nonmagnetic microbubbles of the same size for the same ultrasound exposure (0.5 MHz, 100 kPa, 12-cycle pulse) and that this was minimally affected by an imposed magnetic field. The linear scattering to attenuation ratio (STAR) was also similar for suspensions of both bubble types although the nonlinear STAR was ~50% lower for the magnetic microbubbles. Both the video and acoustic data were supported by the results from theoretical modelling.

Type: Article
Title: Theoretical and experimental characterisation of magnetic microbubbles.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ultrasmedbio.2012.01.027
Publisher version: http://dx.doi.org/10.1016/j.ultrasmedbio.2012.01.0...
Language: English
Additional information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Computer Simulation, Contrast Media, Dose-Response Relationship, Radiation, High-Energy Shock Waves, Magnetic Fields, Materials Testing, Microbubbles, Models, Chemical, Radiation Dosage
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Security and Crime Science
URI: https://discovery.ucl.ac.uk/id/eprint/1344354
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