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Performance on a probabilistic inference task in healthy subjects receiving ketamine compared with patients with schizophrenia

Evans, S; Almahdi, B; Sultan, P; Sohanpal, I; Brandner, B; Collier, T; Shergill, SS; ... Averbeck, BB; + view all (2012) Performance on a probabilistic inference task in healthy subjects receiving ketamine compared with patients with schizophrenia. Journal of Psychopharmacology , 26 (9) 1211 -1217. 10.1177/0269881111435252. Green open access

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Abstract

Evidence suggests that some aspects of schizophrenia can be induced in healthy volunteers through acute administration of the non-competitive NMDA-receptor antagonist, ketamine. In probabilistic inference tasks, patients with schizophrenia have been shown to 'jump to conclusions' (JTC) when asked to make a decision. We aimed to test whether healthy participants receiving ketamine would adopt a JTC response pattern resembling that of patients. The paradigmatic task used to investigate JTC has been the 'urn' task, where participants are shown a sequence of beads drawn from one of two 'urns', each containing coloured beads in different proportions. Participants make a decision when they think they know the urn from which beads are being drawn. We compared performance on the urn task between controls receiving acute ketamine or placebo with that of patients with schizophrenia and another group of controls matched to the patient group. Patients were shown to exhibit a JTC response pattern relative to their matched controls, whereas JTC was not evident in controls receiving ketamine relative to placebo. Ketamine does not appear to promote JTC in healthy controls, suggesting that ketamine does not affect probabilistic inferences.

Type: Article
Title: Performance on a probabilistic inference task in healthy subjects receiving ketamine compared with patients with schizophrenia
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/0269881111435252
Publisher version: http://dx.doi.org/10.1177/0269881111435252
Language: English
Additional information: This article is distributed under the terms of the Creative Commons Attribution-Non Commercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(http://www.uk.sagepub.com/aboutus/openaccess.htm). PMCID: PMC3546628
Keywords: Adult, Anesthetics, Dissociative, Antipsychotic agents, Decision making, Diagnostic and statistical manual of mental disorders, Dose-response relationship, Drug, Double-blind method, Excitatory amino acid antagonists, Female, Humans, Ketamine, Male, Middle Aged, Neurotoxicity syndromes, Patient dropouts, Receptors, N-methyl-d-aspartate, Schizophrenia, Schizophrenic psychology, Severity of illness index, Task performance and analysis, Young adult
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention
URI: https://discovery.ucl.ac.uk/id/eprint/1343108
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