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Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions.

McCormack, M; Urban, TJ; Shianna, KV; Walley, N; Pandolfo, M; Depondt, C; Chaila, E; ... Cavalleri, GL; + view all (2012) Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions. Pharmacogenomics , 13 (4) 399 - 405. 10.2217/pgs.11.165. Green open access

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Abstract

An association between carbamazepine-induced hypersensitivity and HLA-A*3101 has been reported in populations of both European and Asian descent. We aimed to investigate HLA-A*3101 and other common variants across the genome as markers for cutaneous adverse drug reactions (cADRs) attributed to lamotrigine and phenytoin.

Type: Article
Title: Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.2217/pgs.11.165
Publisher version: http://dx.doi.org/10.2217/pgs.11.165
Language: English
Additional information: This work is made available under a Creative Commons license. For full bibliographic citation, please refer to the version available at www.futuremedicine.com
Keywords: Biomarkers, Pharmacological, Carbamazepine, Drug Hypersensitivity, Genome-Wide Association Study, HLA-A Antigens, Humans, Phenytoin, Polymorphism, Single Nucleotide, Triazines
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
URI: https://discovery.ucl.ac.uk/id/eprint/1343070
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