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Neural mechanisms underlying motivation of mental versus physical effort.

Schmidt, L; Lebreton, M; Cléry-Melin, ML; Daunizeau, J; Pessiglione, M; (2012) Neural mechanisms underlying motivation of mental versus physical effort. PLoS Biology , 10 (2) , Article e1001266. 10.1371/journal.pbio.1001266. Green open access

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Abstract

Mental and physical efforts, such as paying attention and lifting weights, have been shown to involve different brain systems. These cognitive and motor systems, respectively, include cortical networks (prefronto-parietal and precentral regions) as well as subregions of the dorsal basal ganglia (caudate and putamen). Both systems appeared sensitive to incentive motivation: their activity increases when we work for higher rewards. Another brain system, including the ventral prefrontal cortex and the ventral basal ganglia, has been implicated in encoding expected rewards. How this motivational system drives the cognitive and motor systems remains poorly understood. More specifically, it is unclear whether cognitive and motor systems can be driven by a common motivational center or if they are driven by distinct, dedicated motivational modules. To address this issue, we used functional MRI to scan healthy participants while performing a task in which incentive motivation, cognitive, and motor demands were varied independently. We reasoned that a common motivational node should (1) represent the reward expected from effort exertion, (2) correlate with the performance attained, and (3) switch effective connectivity between cognitive and motor regions depending on task demand. The ventral striatum fulfilled all three criteria and therefore qualified as a common motivational node capable of driving both cognitive and motor regions of the dorsal striatum. Thus, we suggest that the interaction between a common motivational system and the different task-specific systems underpinning behavioral performance might occur within the basal ganglia.

Type: Article
Title: Neural mechanisms underlying motivation of mental versus physical effort.
Location: US
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pbio.1001266
Publisher version: http://dx.doi.org/10.1371/journal.pbio.1001266
Language: English
Additional information: © 2012 Schmidt et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC3283550
Keywords: Adult, Analysis of Variance, Attention, Basal Ganglia, Female, Games, Experimental, Humans, Linear Models, Magnetic Resonance Imaging, Male, Mental Processes, Motivation, Motor Activity
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/1342942
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