Cassano, M;
Biressi, S;
Finan, A;
Benedetti, L;
Omes, C;
Boratto, R;
Martin, F;
... Sampaolesi, M; + view all
(2008)
Magic-factor 1, a partial agonist of Met, induces muscle hypertrophy by protecting myogenic progenitors from apoptosis.
PLoS One
, 3
(9)
, Article e3223. 10.1371/journal.pone.0003223.
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Abstract
Hepatocyte Growth Factor (HGF) is a pleiotropic cytokine of mesenchymal origin that mediates a characteristic array of biological activities including cell proliferation, survival, motility and morphogenesis. Its high affinity receptor, the tyrosine kinase Met, is expressed by a wide range of tissues and can be activated by either paracrine or autocrine stimulation. Adult myogenic precursor cells, the so called satellite cells, express both HGF and Met. Following muscle injury, autocrine HGF-Met stimulation plays a key role in promoting activation and early division of satellite cells, but is shut off in a second phase to allow myogenic differentiation. In culture, HGF stimulation promotes proliferation of muscle precursors thereby inhibiting their differentiation.
| Type: | Article |
|---|---|
| Title: | Magic-factor 1, a partial agonist of Met, induces muscle hypertrophy by protecting myogenic progenitors from apoptosis. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0003223 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0003223 |
| Language: | English |
| Additional information: | © 2008 Cassano et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC2528937 This work was supported in part by: FWO Odysseus Program n. G.0907.08; Wicka Funds n. zkb8720; the Italian Ministry of University and Scientific Research (grant n. 2005067555_003, COFIN 2006–08), the Muscular Dystrophy Association, Telethon, Association Francoise contre les Myopathies, Parent Project Onlus, CARIPLO. |
| Keywords: | Animals, Apoptosis, Cell Differentiation, Cell Proliferation, Cell Survival, Hypertrophy, Mice, Mice, Knockout, Mice, Transgenic, Models, Biological, Muscles, Phenotype, Proto-Oncogene Proteins c-met, Recombinant Proteins, Sarcoglycans, Stem Cells |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1342599 |
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