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Intraoperative radiotherapy in the treatment of breast cancer: a review of the evidence

Williams, NR; Pigott, KH; Keshtgar, MR; (2011) Intraoperative radiotherapy in the treatment of breast cancer: a review of the evidence. International Journal of Breast Cancer , 2011 , Article 375170. 10.4061/2011/375170. Green open access

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Abstract

The surgical treatment of early breast cancer has evolved from the removal of the entire breast and surrounding tissues (mastectomy) to the removal of the tumour together with a margin of healthy tissue (lumpectomy). Adjuvant radiotherapy, however, is still mainly given to the whole breast. Furthermore, external beam radiotherapy is often given several months after initial surgery and requires the patient to attend the radiotherapy centre daily for several weeks. A single fraction of radiotherapy given during surgery directly to the tumour bed (intraoperative radiotherapy) avoids these problems. The rationale and level-1 evidence for the safety and efficacy of the technique are reviewed.

Type: Article
Title: Intraoperative radiotherapy in the treatment of breast cancer: a review of the evidence
Location: Egypt
Open access status: An open access version is available from UCL Discovery
DOI: 10.4061/2011/375170
Publisher version: http://dx.doi.org/10.4061/2011/375170
Language: English
Additional information: Copyright © 2011 Norman R. Williams et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. PMCID: PMC3262570
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention
URI: https://discovery.ucl.ac.uk/id/eprint/1339497
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