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Prolonged rote learning produces delayed memory facilitation and metabolic changes in the hippocampus of the ageing human brain

Roche, RAP; Mullally, SL; McNulty, JP; Hayden, J; Brennan, P; Doherty, CP; Fitzsimons, M; ... O'Mara, SM; + view all (2009) Prolonged rote learning produces delayed memory facilitation and metabolic changes in the hippocampus of the ageing human brain. BMC Neuroscience , 10 , Article 136. 10.1186/1471-2202-10-136. Green open access

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Abstract

Background: Repeated rehearsal is one method by which verbal material may be transferred from short- to long-term memory. We hypothesised that extended engagement of memory structures through prolonged rehearsal would result in enhanced efficacy of recall and also of brain structures implicated in new learning. Twenty-four normal participants aged 55-70 (mean = 60.1) engaged in six weeks of rote learning, during which they learned 500 words per week every week (prose, poetry etc.). An extensive battery of memory tests was administered on three occasions, each six weeks apart. In addition, proton magnetic resonance spectroscopy (H-1-MRS) was used to measure metabolite levels in seven voxels of interest (VOIs) (including hippocampus) before and after learning.Results: Results indicate a facilitation of new learning that was evident six weeks after rote learning ceased. This facilitation occurred for verbal/episodic material only, and was mirrored by a metabolic change in left posterior hippocampus, specifically an increase in NAA/(Cr+Cho) ratio.Conclusion: Results suggest that repeated activation of memory structures facilitates anamnesis and may promote neuronal plasticity in the ageing brain, and that compliance is a key factor in such facilitation as the effect was confined to those who engaged fully with the training.

Type: Article
Title: Prolonged rote learning produces delayed memory facilitation and metabolic changes in the hippocampus of the ageing human brain
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/1471-2202-10-136
Publisher version: http://dx.doi.org/10.1186/1471-2202-10-136
Language: English
Additional information: © 2009 Roche et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: MAGNETIC-RESONANCE-SPECTROSCOPY, MILD COGNITIVE IMPAIRMENT, TEMPORAL-LOBE EPILEPSY, LONG-TERM POTENTIATION, ALZHEIMERS-DISEASE, ENTORHINAL CORTEX, EPISODIC MEMORY, VISUAL-CORTEX, VERBAL MEMORY, SEIZURE FOCUS
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/1337970
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