UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Posterior cortical atrophy.

Crutch, SJ; Lehmann, M; Schott, JM; Rabinovici, GD; Rossor, MN; Fox, NC; (2012) Posterior cortical atrophy. Lancet Neurology , 11 (2) 170 - 178. 10.1016/S1474-4422(11)70289-7. Green open access

[thumbnail of 1337217.pdf]
Preview
PDF
1337217.pdf

Download (1MB)

Abstract

Posterior cortical atrophy (PCA) is a neurodegenerative syndrome that is characterised by progressive decline in visuospatial, visuoperceptual, literacy, and praxic skills. The progressive neurodegeneration affecting parietal, occipital, and occipitotemporal cortices that underlies PCA is attributable to Alzheimer's disease in most patients. However, alternative underlying causes, including dementia with Lewy bodies, corticobasal degeneration, and prion disease, have also been identified, and not all patients with PCA have atrophy on clinical imaging. This heterogeneity has led to inconsistencies in diagnosis and terminology and difficulties in comparing studies from different centres, and has restricted the generalisability of findings from clinical trials and investigations of factors that drive phenotypic variability. Important challenges remain, including the identification of factors associated not only with the selective vulnerability of posterior cortical regions but also with the young age of onset of PCA. Greater awareness of the syndrome and agreement over the correspondence between syndrome-level and disease-level classifications are needed to improve diagnostic accuracy, clinical management, and the design of research studies.

Type: Article
Title: Posterior cortical atrophy.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/S1474-4422(11)70289-7
Publisher version: http://dx.doi.org/10.1016/S1474-4422(11)70289-7
Language: English
Additional information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Atrophy, Cerebral Cortex, Cognition Disorders, Female, Humans, Neurodegenerative Diseases, Syndrome
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1337217
Downloads since deposit
325Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item