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Neural crest delamination and migration: from epithelium-to-mesenchyme transition to collective cell migration.

Theveneau, E; Mayor, R; (2012) Neural crest delamination and migration: from epithelium-to-mesenchyme transition to collective cell migration. Developmental Biology , 366 (1) 34 - 54. 10.1016/j.ydbio.2011.12.041. Green open access

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Abstract

After induction and specification in the ectoderm, at the border of the neural plate, the neural crest (NC) population leaves its original territory through a delamination process. Soon afterwards, the NC cells migrate throughout the embryo and colonize a myriad of tissues and organs where they settle and differentiate. The delamination involves a partial or complete epithelium-to-mesenchyme transition (EMT) regulated by a complex network of transcription factors including several proto-oncogenes. Studying the relationship between these genes at the time of emigration, and their individual or collective impact on cell behavior, provides valuable information about their role in EMT in other contexts such as cancer metastasis. During migration, NC cells are exposed to large number of positive and negative regulators that control where they go by generating permissive and restricted areas and by modulating their motility and directionality. In addition, as most NC cells migrate collectively, cell-cell interactions play a crucial role in polarizing the cells and interpreting external cues. Cell cooperation eventually generates an overall polarity to the population, leading to directional collective cell migration. This review will summarize our current knowledge on delamination, EMT and migration of NC cells using key examples from chicken, Xenopus, zebrafish and mouse embryos. Given the similarities between neural crest migration and cancer invasion, these cells may represent a useful model for understanding the mechanisms of metastasis.

Type: Article
Title: Neural crest delamination and migration: from epithelium-to-mesenchyme transition to collective cell migration.
Location: US
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ydbio.2011.12.041
Publisher version: http://dx.doi.org/10.1016/j.ydbio.2011.12.041
Language: English
Additional information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Animals, Cell Communication, Cell Movement, Epithelial-Mesenchymal Transition, Gene Expression Regulation, Developmental, Humans, Mice, Neoplasm Invasiveness, Neural Crest, Xenopus, Zebrafish
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/1337167
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