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Assessment of pediatric asthma drug use in three European countries; a TEDDY study.

Sen, EF; Verhamme, KM; Neubert, A; Hsia, Y; Murray, M; Felisi, M; Giaquinto, C; ... TEDDY European Network of Excellence, ; + view all (2011) Assessment of pediatric asthma drug use in three European countries; a TEDDY study. Eur J Pediatr , 170 (1) 81 - 92. 10.1007/s00431-010-1275-7. Green open access

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Abstract

Asthma drugs are amongst the most frequently used drugs in childhood, but international comparisons on type and indication of use are lacking. The aim of this study was to describe asthma drug use in children with and without asthma in the Netherlands (NL), Italy (IT), and the United Kingdom (UK). We conducted a retrospective analysis of outpatient medical records of children 0-18 years from 1 January 2000 until 31 December 2005. For all children, prescription rates of asthma drugs were studied by country, age, asthma diagnosis, and off-label status. One-year prevalence rates were calculated per 100 children per patient-year (PY). The cohort consisted of 671,831 children of whom 49,442 had been diagnosed with asthma at any time during follow-up. ß2-mimetics and inhaled steroids were the most frequently prescribed asthma drug classes in NL (4.9 and 4.1/100 PY), the UK (8.7 and 5.3/100 PY) and IT (7.2 and 16.2/100 PY), respectively. Xanthines, anticholinergics, leukotriene receptor antagonists, and anti-allergics were prescribed in less than one child per 100 per year. In patients without asthma, ß2-mimetics were used most frequently. Country differences were highest for steroids, (Italy highest), and for ß2-mimetics (the UK highest). Off-label use was low, and most pronounced for ß2-mimetics in children <18 months (IT) and combined ß2-mimetics + anticholinergics in children <6 years (NL). CONCLUSION: This study shows that among all asthma drugs, ß2-mimetics and inhaled steroids are most often used, also in children without asthma, and with large variability between countries. Linking multi-country databases allows us to study country specific pediatric drug use in a systematic manner without being hampered by methodological differences. This study underlines the potency of healthcare databases in rapidly providing data on pediatric drug use and possibly safety.

Type: Article
Title: Assessment of pediatric asthma drug use in three European countries; a TEDDY study.
Location: Germany
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00431-010-1275-7
Publisher version: http://dx.doi.org/10.1007/s00431-010-1275-7
Language: English
Additional information: Copyright The Author(s) 2010. This article is published with open access at Springerlink.com. PMCID: PMC3016194
Keywords: Adolescent, Adrenergic beta-Agonists, Anti-Allergic Agents, Asthma, Child, Child, Preschool, Cholinergic Antagonists, Cohort Studies, Corticosterone, Drug Therapy, Combination, Female, Great Britain, Humans, Infant, Italy, Male, Netherlands, Off-Label Use, Retrospective Studies
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Practice and Policy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
URI: https://discovery.ucl.ac.uk/id/eprint/1335928
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