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Annexin A2 at the interface of actin and membrane dynamics: a focus on its roles in endocytosis and cell polarization

Grieve, AG; Moss, SE; Hayes, MJ; (2012) Annexin A2 at the interface of actin and membrane dynamics: a focus on its roles in endocytosis and cell polarization. International Journal of Cell Biology , Article 852430. 10.1155/2012/852430. Green open access

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Abstract

Annexins are a family of calcium- and phospholipid-binding proteins found in nearly all eukaryotes. They are structurally highly conserved and have been implicated in a wide range of cellular activities. In this review we focus on Annexin A2 (AnxA2). Altered expression of this protein has been identified in a wide variety of cancers, has also been found on the HIV particle and has been implicated in the maturation of the virus. Recently it has also been shown to have an important role in the establishment of normal apical polarity in epithelial cells. We synthesize here the known biochemical properties of this protein, and the extensive literature concerning its involvement in the endocytic pathway. We stress the importance of AnxA2 as a platform for actin remodeling in the vicinity of dynamic cellular membranes, in the hope that this may shed light on the normal functions of the protein and its contribution to disease.

Type: Article
Title: Annexin A2 at the interface of actin and membrane dynamics: a focus on its roles in endocytosis and cell polarization
Open access status: An open access version is available from UCL Discovery
DOI: 10.1155/2012/852430
Publisher version: http://dx.doi.org/10.1155/2012/852430
Language: English
Additional information: Copyright © 2012 Adam G. Grieve et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/1335454
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