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Roadmap and standard operating procedures for biobanking and discovery of neurochemical markers in ALS

Otto, M; Bowser, R; Turner, M; Berry, J; Brettschneider, J; Connor, J; Costa, J; ... Volcano Group; + view all (2012) Roadmap and standard operating procedures for biobanking and discovery of neurochemical markers in ALS. Amyotrophic Lateral Sclerosis , 13 (1) 1 - 10. 10.3109/17482968.2011.627589. Green open access

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Abstract

Despite major advances in deciphering the neuropathological hallmarks of amyotrophic lateral sclerosis (ALS), validated neurochemical biomarkers for monitoring disease activity, earlier diagnosis, defining prognosis and unlocking key pathophysiological pathways are lacking. Although several candidate biomarkers exist, translation into clinical application is hindered by small sample numbers, especially longitudinal, for independent verification. This review considers the potential routes to the discovery of neurochemical markers in ALS, and provides a consensus statement on standard operating procedures that will facilitate multicenter collaboration, validation and ultimately clinical translation.

Type: Article
Title: Roadmap and standard operating procedures for biobanking and discovery of neurochemical markers in ALS
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.3109/17482968.2011.627589
Publisher version: http://dx.doi.org/10.3109/17482968.2011.627589
Language: English
Additional information: This is an electronic version of an article published in Otto, M and Bowser, R and Turner, M and Berry, J and Brettschneider, J and Connor, J and Costa, J and Cudkowicz, M and Glass, J and Jahn, O and Lehnert, S and Malaspina, A and Parnetti, L and Petzold, A and Shaw, P and Sherman, A and Steinacker, P and Süssmuth, S and Teunissen, C and Tumani, H and Wuolikainen, A and Ludolph, A and Volcano Group, (2012) Roadmap and standard operating procedures for biobanking and discovery of neurochemical markers in ALS. Amyotrophic Lateral Sclerosis, 13 (1) 1 - 10. Amyotrophic Lateral Sclerosis is available online at http://dx.doi.org/10.3109/17482968.2011.627589
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
URI: https://discovery.ucl.ac.uk/id/eprint/1335412
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