UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Genetic association study of NF-κB genes in UK Caucasian adult and juvenile onset idiopathic inflammatory myopathy

Chinoy, H; Li, CK; Platt, H; Fertig, N; Varsani, H; Gunawardena, H; Betteridge, Z; ... UK Adult Onset Myositis Immunogenetic Consortium and UK Juvenile; + view all (2012) Genetic association study of NF-κB genes in UK Caucasian adult and juvenile onset idiopathic inflammatory myopathy. Rheumatology , 51 (5) 794 -799. 10.1093/rheumatology/ker379. Green open access

[thumbnail of Rheumatology-2012-Chinoy-794-9.pdf]
Preview
PDF
Rheumatology-2012-Chinoy-794-9.pdf

Download (92kB)
[thumbnail of Supplementary Data 1] MS Word (Supplementary Data 1)
rhe-11-0544-File002.doc

Download (127kB)
[thumbnail of Supplementary Data 2] MS Word (Supplementary Data 2)
rhe-11-0544-File003.doc

Download (20kB)

Abstract

Treatment-resistant muscle wasting is an increasingly recognized problem in idiopathic inflammatory myopathy (IIM). TNF-α is thought to induce muscle catabolism via activation of nuclear factor-kappa B (NF-κB). Several genes share homology with the NF-κB family of proteins. This study investigated the role of NF-κB-related genes in disease susceptibility in UK Caucasian IIM.

Type: Article
Title: Genetic association study of NF-κB genes in UK Caucasian adult and juvenile onset idiopathic inflammatory myopathy
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/rheumatology/ker379
Publisher version: http://dx.doi.org/10.1093/rheumatology/ker379
Language: English
Additional information: © The Author(s) 2011. Published by Oxford University Press on behalf of The British Society for Rheumatology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. PMCID: PMC3327167
Keywords: Adolescent, Adult, Aged, Alleles, European Continental Ancestry Group, Female, Genetic Association Studies, Genetic Predisposition to Disease, Genotype, Great Britain, Haplotypes, Histocompatibility Antigens Class II, Humans, Male, Middle Aged, Myositis, NF-kappa B, Polymorphism, Single Nucleotide, Tumor Necrosis Factor-alpha
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > ICH - Laboratory Management
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1335194
Downloads since deposit
219Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item