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Telomeric NAP1L4 and OSBPL5 of the KCNQ1 cluster, and the DECORIN gene are not imprinted in human trophoblast stem cells.

Frost, JM; Udayashankar, R; Moore, HD; Moore, GE; (2010) Telomeric NAP1L4 and OSBPL5 of the KCNQ1 cluster, and the DECORIN gene are not imprinted in human trophoblast stem cells. PLOS One , 5 (7) , Article e11595. 10.1371/journal.pone.0011595. Green open access

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Abstract

Genomic imprinting of the largest known cluster, the Kcnq1/KCNQ1 domain on mChr7/hChr11, displays significant differences between mouse and man. Of the fourteen transcripts in this cluster, imprinting of six is ubiquitous in mice and humans, however, imprinted expression of the other eight transcripts is only found in the mouse placenta. The human orthologues of the latter eight transcripts are biallelically expressed, at least from the first trimester onwards. However, as early development is less divergent between species, placental specific imprinting may be present in very early gestation in both mice and humans.

Type: Article
Title: Telomeric NAP1L4 and OSBPL5 of the KCNQ1 cluster, and the DECORIN gene are not imprinted in human trophoblast stem cells.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0011595
Publisher version: http://dx.doi.org/10.1371/journal.pone.0011595
Language: English
Additional information: © 2010 Frost et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. JMF was an MRC PhD Student. The work in GEM research group at ICH laboratory is supported by the MRC, Wellcome Trust, SPARKS and Wellbeing of Women. RU is grateful to the Infertility Research Trust for her studentship. Aspects of the study in Sheffield were also supported by the Medical Research Council and Sheffield Hospitals Charitable Trust. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Keywords: Alleles, Animals, Cells, Cultured, Decorin, Embryonic Stem Cells, Extracellular Matrix Proteins, Female, Genomic Imprinting, Genotype, Humans, KCNQ1 Potassium Channel, Mice, Nuclear Proteins, Pregnancy, Proteoglycans, Receptors, Steroid, Reverse Transcriptase Polymerase Chain Reaction, Trophoblasts
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
URI: https://discovery.ucl.ac.uk/id/eprint/1335085
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