Galizia, EC;
Srikantha, M;
Palmer, R;
Waters, JJ;
Lench, N;
Ogilvie, CM;
Kasperavičiūtė, D;
... Sisodiya, SM; + view all
(2012)
Array comparative genomic hybridization: results from an adult population with drug-resistant epilepsy and co-morbidities.
European Journal of Medical Genetics
, 55
(5)
342 - 348.
10.1016/j.ejmg.2011.12.011.
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Abstract
The emergence of array comparative genomic hybridization (array CGH) as a diagnostic tool in molecular genetics has facilitated recognition of microdeletions and microduplications as risk factors for both generalised and focal epilepsies. Furthermore, there is evidence that some microdeletions/duplications, such as the 15q13.3 deletion predispose to a range of neuropsychiatric disorders, including intellectual disability (ID), autism, schizophrenia and epilepsy. We hypothesised that array CGH would reveal relevant findings in an adult patient group with epilepsy and complex phenotypes.
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