Alam-Faruque, Y;
Huntley, RP;
Khodiyar, VK;
Camon, EB;
Dimmer, EC;
Sawford, T;
Martin, MJ;
... Lovering, RC; + view all
(2011)
The impact of focused Gene Ontology curation of specific mammalian systems.
PLOS One
, 6
(12)
, Article e27541. 10.1371/journal.pone.0027541.
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Abstract
The Gene Ontology (GO) resource provides dynamic controlled vocabularies to provide an information-rich resource to aid in the consistent description of the functional attributes and subcellular locations of gene products from all taxonomic groups (www.geneontology.org). System-focused projects, such as the Renal and Cardiovascular GO Annotation Initiatives, aim to provide detailed GO data for proteins implicated in specific organ development and function. Such projects support the rapid evaluation of new experimental data and aid in the generation of novel biological insights to help alleviate human disease. This paper describes the improvement of GO data for renal and cardiovascular research communities and demonstrates that the cardiovascular-focused GO annotations, created over the past three years, have led to an evident improvement of microarray interpretation. The reanalysis of cardiovascular microarray datasets confirms the need to continue to improve the annotation of the human proteome. AVAILABILITY: GO ANNOTATION DATA IS FREELY AVAILABLE FROM: ftp://ftp.geneontology.org/pub/go/gene-associations/
| Type: | Article |
|---|---|
| Title: | The impact of focused Gene Ontology curation of specific mammalian systems. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0027541 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0027541 |
| Language: | English |
| Additional information: | © 2011 Alam-Faruque et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The Renal GOA Initiative is funded by the Kidney Research UK www.kidneyresearchuk.org Project Grant RP26/2008. The Cardiovascular GOA Initiative is funded by the British Heart Foundation www.bhf.org.uk Grant SP/07/007/23671. The UniProtKB-GOA project is supported by the National Institutes of Health www.nih.gov grant number R01HG02273-02 and European Molecular Biology Laboratory www.embl.de. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
| Keywords: | Animals, Databases, Genetic, High-Throughput Nucleotide Sequencing, Humans, Kidney, Macrophages, Mammals, Molecular Sequence Annotation, Oligonucleotide Array Sequence Analysis, Statistics as Topic |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1333929 |
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