UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

The impact of focused Gene Ontology curation of specific mammalian systems.

Alam-Faruque, Y; Huntley, RP; Khodiyar, VK; Camon, EB; Dimmer, EC; Sawford, T; Martin, MJ; ... Lovering, RC; + view all (2011) The impact of focused Gene Ontology curation of specific mammalian systems. PLOS One , 6 (12) , Article e27541. 10.1371/journal.pone.0027541. Green open access

[img]
Preview
PDF
1333929.pdf

Download (494kB)

Abstract

The Gene Ontology (GO) resource provides dynamic controlled vocabularies to provide an information-rich resource to aid in the consistent description of the functional attributes and subcellular locations of gene products from all taxonomic groups (www.geneontology.org). System-focused projects, such as the Renal and Cardiovascular GO Annotation Initiatives, aim to provide detailed GO data for proteins implicated in specific organ development and function. Such projects support the rapid evaluation of new experimental data and aid in the generation of novel biological insights to help alleviate human disease. This paper describes the improvement of GO data for renal and cardiovascular research communities and demonstrates that the cardiovascular-focused GO annotations, created over the past three years, have led to an evident improvement of microarray interpretation. The reanalysis of cardiovascular microarray datasets confirms the need to continue to improve the annotation of the human proteome. AVAILABILITY: GO ANNOTATION DATA IS FREELY AVAILABLE FROM: ftp://ftp.geneontology.org/pub/go/gene-associations/

Type: Article
Title: The impact of focused Gene Ontology curation of specific mammalian systems.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0027541
Publisher version: http://dx.doi.org/10.1371/journal.pone.0027541
Language: English
Additional information: © 2011 Alam-Faruque et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The Renal GOA Initiative is funded by the Kidney Research UK www.kidneyresearchuk.org Project Grant RP26/2008. The Cardiovascular GOA Initiative is funded by the British Heart Foundation www.bhf.org.uk Grant SP/07/007/23671. The UniProtKB-GOA project is supported by the National Institutes of Health www.nih.gov grant number R01HG02273-02 and European Molecular Biology Laboratory www.embl.de. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Keywords: Animals, Databases, Genetic, High-Throughput Nucleotide Sequencing, Humans, Kidney, Macrophages, Mammals, Molecular Sequence Annotation, Oligonucleotide Array Sequence Analysis, Statistics as Topic
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1333929
Downloads since deposit
120Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item