Reddington, K;
O'Grady, J;
Dorai-Raj, S;
Niemann, S;
van Soolingen, D;
Barry, T;
(2011)
A novel multiplex real-time PCR for the identification of mycobacteria associated with zoonotic tuberculosis.
PLoS One
, 6
(8)
, Article e23481. 10.1371/journal.pone.0023481.
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Abstract
Tuberculosis (TB) is the leading cause of death worldwide from a single infectious agent. An ability to detect the Mycobacterium tuberculosis complex (MTC) in clinical material while simultaneously differentiating its members is considered important. This allows for the gathering of epidemiological information pertaining to the prevalence, transmission and geographical distribution of the MTC, including those MTC members associated with zoonotic TB infection in humans. Also differentiating between members of the MTC provides the clinician with inherent MTC specific drug susceptibility profiles to guide appropriate chemotherapy.
| Type: | Article |
|---|---|
| Title: | A novel multiplex real-time PCR for the identification of mycobacteria associated with zoonotic tuberculosis. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0023481 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0023481 |
| Language: | English |
| Additional information: | © 2011 Reddington et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. College of Sciences, National University of Ireland Galway funded KR Postgraduate Scholarship (http://www.nuigalway.ie/science/scholarshipsandprizes.html). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
| Keywords: | Animals, Cattle, DNA Primers, DNA, Bacterial, Humans, Mycobacterium, Mycobacterium bovis, Mycobacterium tuberculosis, Real-Time Polymerase Chain Reaction, Reproducibility of Results, Sensitivity and Specificity, Sequence Analysis, DNA, Species Specificity, Tuberculosis, Tuberculosis, Bovine, Zoonoses |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1333817 |
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