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Frontal lobe function in temporal lobe epilepsy.

Stretton, J; Thompson, PJ; (2012) Frontal lobe function in temporal lobe epilepsy. Epilepsy Research , 98 (1) 1 - 13. 10.1016/j.eplepsyres.2011.10.009. Green open access

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Abstract

Temporal lobe epilepsy (TLE) is typically associated with long-term memory dysfunction. The frontal lobes support high-level cognition comprising executive skills and working memory that is vital for daily life functioning. Deficits in these functions have been increasingly reported in TLE. Evidence from both the neuropsychological and neuroimaging literature suggests both executive function and working memory are compromised in the presence of TLE. In relation to executive impairment, particular focus has been paid to set shifting as measured by the Wisconsin Card Sorting Task. Other discrete executive functions such as decision-making and theory of mind also appear vulnerable but have received little attention. With regard to working memory, the medial temporal lobe structures appear have a more critical role, but with emerging evidence of hippocampal dependent and independent processes. The relative role of underlying pathology and seizure spread is likely to have considerable bearing upon the cognitive phenotype and trajectory in TLE. The identification of the nature of frontal lobe dysfunction in TLE thus has important clinical implications for prognosis and surgical management. Longitudinal neuropsychological and neuroimaging studies assessing frontal lobe function in TLE patients pre- and postoperatively will improve our understanding further.

Type: Article
Title: Frontal lobe function in temporal lobe epilepsy.
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.eplepsyres.2011.10.009
Publisher version: http://dx.doi.org/10.1016/j.eplepsyres.2011.10.009
Language: English
Additional information: This work is made available under a Creative Commons license. PMCID: PMC3398387
Keywords: Attention, Epilepsy, Temporal Lobe, Executive Function, Frontal Lobe, Humans, Memory, Short-Term, Neuropsychological Tests, Temporal Lobe
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
URI: https://discovery.ucl.ac.uk/id/eprint/1332557
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