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Association of a sequence variant in DAB2IP with coronary heart disease

Harrison, SC; Cooper, JA; Li, K; Talmud, PJ; Sofat, R; Stephens, JW; Hamsten, A; ... Humphries, SE; + view all (2012) Association of a sequence variant in DAB2IP with coronary heart disease. European Heart Journal , 33 (7) 881 -888. 10.1093/eurheartj/ehr075. Green open access

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Abstract

A sequence variant, rs7025486[A], in DAB2IP on chromosome 9q33 has recently been associated with coronary heart disease (CHD). We sought to replicate this finding and to investigate associations with a panel of inflammatory and haemostatic biomarkers. We also sought to examine whether this variant, in combination with a chromosome 9p21 CHD variant (rs10757278) and the Framingham risk score (FRS), could improve the prediction of events compared with the FRS alone.

Type: Article
Title: Association of a sequence variant in DAB2IP with coronary heart disease
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/eurheartj/ehr075
Publisher version: http://dx.doi.org/10.1093/eurheartj/ehr075
Language: English
Additional information: © The Author 2011. The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that the original authorship is properly and fully attributed; the Journal, Learned Society and Oxford University Press are attributed as the original place of publication with correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oup.com. PMCID: PMC3345557
Keywords: Aged, Case-Control Studies, Chromosomes, Human, Pair 9, Coronary Disease, Female, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Polymorphism, Single Nucleotide, Prospective Studies, ROC Curve, Risk Factors, ras GTPase-Activating Proteins
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Internal Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics > Clinical Epidemiology
URI: https://discovery.ucl.ac.uk/id/eprint/1332499
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