Harrison, SC;
Cooper, JA;
Li, K;
Talmud, PJ;
Sofat, R;
Stephens, JW;
Hamsten, A;
... Humphries, SE; + view all
(2012)
Association of a sequence variant in DAB2IP with coronary heart disease.
European Heart Journal
, 33
(7)
881 -888.
10.1093/eurheartj/ehr075.
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Abstract
A sequence variant, rs7025486[A], in DAB2IP on chromosome 9q33 has recently been associated with coronary heart disease (CHD). We sought to replicate this finding and to investigate associations with a panel of inflammatory and haemostatic biomarkers. We also sought to examine whether this variant, in combination with a chromosome 9p21 CHD variant (rs10757278) and the Framingham risk score (FRS), could improve the prediction of events compared with the FRS alone.
| Type: | Article |
|---|---|
| Title: | Association of a sequence variant in DAB2IP with coronary heart disease |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/eurheartj/ehr075 |
| Publisher version: | http://dx.doi.org/10.1093/eurheartj/ehr075 |
| Language: | English |
| Additional information: | © The Author 2011. The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that the original authorship is properly and fully attributed; the Journal, Learned Society and Oxford University Press are attributed as the original place of publication with correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oup.com. PMCID: PMC3345557 |
| Keywords: | Aged, Case-Control Studies, Chromosomes, Human, Pair 9, Coronary Disease, Female, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Polymorphism, Single Nucleotide, Prospective Studies, ROC Curve, Risk Factors, ras GTPase-Activating Proteins |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics > Clinical Epidemiology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1332499 |
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