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Dendritic cells in tissues: in situ stimulation of immunity and immunopathology

Bennett, CL; Chakraverty, R; (2012) Dendritic cells in tissues: in situ stimulation of immunity and immunopathology. Trends in Immunology , 33 (1) pp. 8-13. 10.1016/j.it.2011.09.008. Green open access

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Abstract

Dendritic cells (DCs) prime and orchestrate naïve T cell immunity in lymphoid organs, but recent data also highlight the importance of DC–effector T cell interactions in tissues. These studies suggest that effector T cells require a second activating step in situ from tissue DCs to become fully competent for effector functions and/or proliferation and survival. DC stimulation of effector T cells within tissues has evolved as a mechanism to ensure that T cells are activated to their full potential only at the site of ongoing infection. Here, we propose that under conditions of uncontrolled inflammation and release of tissue antigens, the same DC-dependent checkpoint perpetuates a destructive response and immunopathology.

Type: Article
Title: Dendritic cells in tissues: in situ stimulation of immunity and immunopathology
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.it.2011.09.008
Publisher version: http://dx.doi.org/10.1016/j.it.2011.09.008
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: IMMUNOLOGY, INFLUENZA-VIRUS INFECTION, REGULATORY T-CELLS, PROTECTIVE IMMUNITY, NONLYMPHOID TISSUES, LYMPH-NODES, B-CELLS, EFFECTOR, ACTIVATION, MIGRATION, RESPONSES
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: https://discovery.ucl.ac.uk/id/eprint/1330517
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