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Genetic variation in complement regulators and susceptibility to age-related macular degeneration.

Cipriani, V; Matharu, BK; Khan, JC; Shahid, H; Stanton, CM; Hayward, C; Wright, AF; ... Yates, JR; + view all (2012) Genetic variation in complement regulators and susceptibility to age-related macular degeneration. Immunobiology , 217 (2) 158 - 161. 10.1016/j.imbio.2011.09.002. Green open access

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Abstract

Age-related macular degeneration (AMD) is the commonest cause of blindness in Western populations. Risk is influenced by age, genetic and environmental factors. Complement activation appears to be important in the pathogenesis and associations have been found between AMD and genetic variations in complement regulators such as complement factor H. We therefore investigated other complement regulators for association with AMD.

Type: Article
Title: Genetic variation in complement regulators and susceptibility to age-related macular degeneration.
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.imbio.2011.09.002
Publisher version: http://dx.doi.org/10.1016/j.imbio.2011.09.002
Language: English
Additional information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC3657157
Keywords: Aged, Aged, 80 and over, Aging, Antigens, CD46, Antigens, CD55, Antigens, CD59, Case-Control Studies, Complement System Proteins, Female, Genetic Association Studies, Genetic Predisposition to Disease, Genetic Variation, Genotype, Humans, Macular Degeneration, Male, Polymorphism, Single Nucleotide, Properdin
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/1329663
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