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IRS1 gene variants, dysglycaemic metabolic changes and type-2 diabetes risk.

Yiannakouris, N; Cooper, JA; Shah, S; Drenos, F; Ireland, HA; Stephens, JW; Li, KW; ... Humphries, SE; + view all (2012) IRS1 gene variants, dysglycaemic metabolic changes and type-2 diabetes risk. Nutrition, Metabolism and Cardiovascular Diseases , 22 (12) 1024 - 1030. 10.1016/j.numecd.2011.05.009. Green open access

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Abstract

A recent genome-wide association study identified rs2943641C > T, 500 kb from the insulin receptor substrate-1 gene (IRS1), as a type-2 diabetes (T2D) susceptibility locus. We aimed to replicate this association by meta-analysis and examine whether common variants within IRS1, present on the HumanCVD BeadChip, were associated with T2D risk.

Type: Article
Title: IRS1 gene variants, dysglycaemic metabolic changes and type-2 diabetes risk.
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.numecd.2011.05.009
Publisher version: http://dx.doi.org/10.1016/j.numecd.2011.05.009
Language: English
Additional information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC3657179
Keywords: Alleles, Case-Control Studies, Computer Simulation, Diabetes Mellitus, Type 2, Europe, European Continental Ancestry Group, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Glucose Tolerance Test, Homeostasis, Humans, Insulin Receptor Substrate Proteins, Insulin Resistance, Linkage Disequilibrium, Logistic Models, Multivariate Analysis, Odds Ratio, Polymorphism, Single Nucleotide, Prevalence, Promoter Regions, Genetic, Risk Factors
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
URI: https://discovery.ucl.ac.uk/id/eprint/1324190
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