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Geographic patterns of genome admixture in Latin American mestizos

Wang, S; Ray, N; Rojas, W; Parra, MV; Bedoya, G; Gallo, C; Poletti, G; ... Ruiz-Linares, A; + view all (2008) Geographic patterns of genome admixture in Latin American mestizos. PLOS GENET , 4 (3) , Article e1000037. 10.1371/journal.pgen.1000037. Green open access

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Abstract

The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly European and Native settlement) from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites. We found extensive variation in Native American and European ancestry ( and generally low levels of African ancestry) among populations and individuals, and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women. An admixture analysis allowing for Native American population subdivision revealed a differentiation of the Native American ancestry amongst Mestizos. This observation is consistent with the genetic structure of pre-Columbian populations and with admixture having involved Natives from the area where the Mestizo examined are located. Our findings agree with available information on the demographic history of Latin America and have a number of implications for the design of association studies in population from the region.

Type: Article
Title: Geographic patterns of genome admixture in Latin American mestizos
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pgen.1000037
Publisher version: http://dx.doi.org/10.1371/journal.pgen.1000037
Language: English
Additional information: © 2008 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: Funding for this work was provided by the following sources: AR-L (NIH R01NS043538); FR (Fondecyt Proyecto 1050595); MCB, MLPE, and FMS (Institutos do Milênio and Apoio a Núcleos de Excelência Programs, Conselho Nacional de Desenvolvimento Científico e Tecnológico). MCB and FMS (Fundacão de Amparo à Pesquisa do Estado do Rio Grande do Sul). MLPE (Fundação Araucária). NBF (NIH R01MH049499, R01NS37484), JED, ELA, NOB, and G.Bailliet (CONICET, CICPBA and ANPCyT Argentina). G.Bedoya (Colciencias and Universidad de Antioquia). NR and LE (Swiss NSF grant No. 3100-112072). SW was supported by an Overseas Research Studentship (UK) and a KC Wong Studentship. Genotyping at the Marshfield Foundation Mammalian Genotyping Service was supported by the National Heart, Lung, and Blood Institute.
Keywords: NUCLEOTIDE-POLYMORPHISM PANEL, MULTILOCUS GENOTYPE DATA, LINKAGE DISEQUILIBRIUM, GENETIC-STRUCTURE, COSTA-RICA, POPULATION, ANCESTRY, DISEASE, MAP, INFORMATION
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > UCL Interaction Centre
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
URI: https://discovery.ucl.ac.uk/id/eprint/1320165
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