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Genetic variation and population structure in Native Americans

Wang, S; Lewis, CM; Jakobsson, M; Ramachandran, S; Ray, N; Bedoya, G; Rojas, W; ... Ruiz-Linares, A; + view all (2007) Genetic variation and population structure in Native Americans. PLOS GENET , 3 (11) , Article e185. 10.1371/journal.pgen.0030185. Green open access

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We examined genetic diversity and population structure in the American landmass using 678 autosomal microsatellite markers genotyped in 422 individuals representing 24 Native American populations sampled from North, Central, and South America. These data were analyzed jointly with similar data available in 54 other indigenous populations worldwide, including an additional five Native American groups. The Native American populations have lower genetic diversity and greater differentiation than populations from other continental regions. We observe gradients both of decreasing genetic diversity as a function of geographic distance from the Bering Strait and of decreasing genetic similarity to Siberians-signals of the southward dispersal of human populations from the northwestern tip of the Americas. We also observe evidence of: ( 1) a higher level of diversity and lower level of population structure in western South America compared to eastern South America, ( 2) a relative lack of differentiation between Mesoamerican and Andean populations, ( 3) a scenario in which coastal routes were easier for migrating peoples to traverse in comparison with inland routes, and ( 4) a partial agreement on a local scale between genetic similarity and the linguistic classification of populations. These findings offer new insights into the process of population dispersal and differentiation during the peopling of the Americas.

Type: Article
Title: Genetic variation and population structure in Native Americans
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pgen.0030185
Publisher version: http://dx.doi.org/10.1371/journal.pgen.0030185
Language: English
Additional information: © 2007 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: Support for this work was provided by Canadian Institutes of Health Research grant MOP-67150 (DL), Fondecyt Proyecto 1050595 (FR), Swiss National Foundation grant 3100A0–112072 (LE), National Institutes of Health grants R01NS043538 (ARL) and GM28016 (MWF), by a postdoctoral fellowship from the Center for Genetics in Health and Medicine at the University of Michigan (MJ), by a UK Overseas Research Studentship, a K. C. Wong Studentship (SW), and by a postdoctoral fellowship from NIH training grant T32 HG00040 (CML). Grant support was also provided by Colciencias (GB), Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (MCB and FMS), the Fundação Araucária (MLPE), Universidad de Antioquia (GB), the Brazilian Institutos do Milênio and Apoio a Núcleos de Excelência Programs, Conselho Nacional de Desenvolvimento Científico e Tecnológico (MCB, MLPE and FMS), the Burroughs Wellcome Fund (NAR), and the Alfred P. Sloan Foundation (NAR). Part of this work was completed during visits of SW to the lab of NAR, supported by a Charlotte and Yule Bogue Research Fellowship from University College London and by a grant from the Horace H. Rackham School of Graduate Studies at the University of Michigan. Genotyping at the Mammalian Genotyping Service was supported by the National Heart, Lung, and Blood Institute.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
URI: https://discovery.ucl.ac.uk/id/eprint/1319398
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